apalutamide will minimize the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicines which have been CYP3A4 substrates may lead to lower exposure to those remedies.Review Cellular applications to lower depressive sy